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Preventing type 2 diabetes: what have we learned?

Massachusetts General Hospital, Diabetes Center, 50 Staniford Street, Boston, MA 02114, USA, dnathan{at}partners.org

The substantial burden of morbidity and mortality associated with type 2 diabetes and the high costs associated with the management of diabetic complications highlight the need for the development of strategies for the prevention of diabetes. Impaired glucose tolerance is a pre-diabetic state which may present an opportunity for intervention to prevent the onset of clinical diabetes. Four recent clinical trials, the DPP, the FDPS, the STOP-NIDDM and the Da Qing study, have evaluated interventions based on diet and exercise and/or pharmacotherapy in pre-diabetic subjects. In all these trials the intervention strategies significantly reduced the incidence of diabetes. A worldwide epidemic of type 2 diabetes will occur over the coming decades and translating the results of these studies into practical and effective initiatives for diabetes prevention is an urgent clinical priority. Br J Diabetes Vasc Dis 2003;3(suppl 1):S6—S11

Key Words: impaired glucose tolerance • type 2 diabetes • metformin • diabetes prevention.

The British Journal of Diabetes & Vascular Disease, Vol. 3, No. 1 suppl, S6-S11 (2003)
DOI: 10.1177/14746514030030010301


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