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The British Journal of Diabetes & Vascular Disease
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Review: Diabetes as a procoagulant condition

Cornelis Kluft

Gaubius Laboratory, TNO-PG, Leiden, The Netherlands, Thrombosis Institute, University of Southern Denmark, Esbjerg, Denmark, c.kluft{at}pg.tno.nl

Jorgen Jespersen

Thrombosis Institute, University of Southern Denmark, Esbjerg, Denmark

Major known effects of the metabolic derangements of diabetes in haemostasis are induction of platelet-vascular activation by hyperglycaemia, the increase in fibrinogen, modification of fibrin substrate by glucose and hypofibrinolysis related to insulin resistance. The platelet effects are specifically expressed during high shear stress and may be relevant in particular for developing of micro-angiopathy. Hypofibrinolysis, increased fibrinogen and modifications of fibrin may aggravate microthrombosis and organ damage and contribute to precipitation of coronary and cerebral infarction. In addition to specific anti-diabetic medication to reduce the haemostatic effects, specific antiplatelet and profibrinolytic treatments may be relevant for reducing further the morbidity and mortality in diabetics for both micro- and macro-angiopathy.

Key Words: diabetes • platelet • fibrinogen • hypofibrinolysis.

The British Journal of Diabetes & Vascular Disease, Vol. 2, No. 5, 358-362 (2002)
DOI: 10.1177/14746514020020050301
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