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The British Journal of Diabetes & Vascular Disease
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Review: The pathogenesis of type 2 diabetes and cardiovascular disease

Steven P Marso

The Mid America Heart Institute, Saint Lukes Hospital, 4401 Wornall, Kansas City, Missouri 64111, USA, smarso{at}saint-lukes.org

Type 2 diabetes mellitus is increasing in prevalence, and is a potent risk factor for the development of atherosclerotic vascular disease and increased risk of adverse cardiovascular events. Approximately 15—25% of patients presenting with ischaemic heart disease have a history of diabetes mellitus. This cohort of patients continues to be at heightened short and long-term risk. This review highlights the many proposed biological drivers that likely play a deterministic role in the cardiovascular outcome of patients with type 2 diabetes mellitus.

Key Words: coronary artery disease • thrombosis • type 2 diabetes mellitus • myocardial infarction • atherosclerosis.

The British Journal of Diabetes & Vascular Disease, Vol. 2, No. 5, 350-356 (2002)
DOI: 10.1177/14746514020020050201
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