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The British Journal of Diabetes & Vascular Disease
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Human islet transplantation: expectation versus reality

Karen Heald

Tessa Jay

Richard Downing

The Islet Research Laboratory, Worcestershire Clinical Research Unit, Worcestershire Acute Hospitals NHS Trust, Worcester Royal Infirmary, Newtown Road, Worcester, WR5 1HN, rd{at}isletlab.org.uk

Although experimental islet isolation and transplantation has continued for over 25 years, the results of human islet transplantation in patients with type 1 diabetes were disappointing until June 2000 when the University of Alberta, Edmonton, Canada reported 100% insulin independence in a cohort of seven patients. The study introduced several innovations now under evaluation worldwide. In the United Kingdom, an Islet Transplant Consortium has been established to co-ordinate clinical trials in several centres. The Canadian results have renewed hope of establishing islet transplantation as a treatment for diabetes while highlighting the need to identify plentiful sources of insulin secreting tissue and alternatives to current immunosuppressive therapies.

Key Words: islet transplantation • type 1 diabetes.

The British Journal of Diabetes & Vascular Disease, Vol. 1, No. 2, 128-130 (2001)
DOI: 10.1177/14746514010010021201
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