Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
The British Journal of Diabetes & Vascular Disease
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Perry, C.
Right arrow Articles by Petrie, J.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Reviews

Review: Adipose tissue: passive sump or active pump?

Colin Perry

University Departments of Medicine, Glasgow Royal Infirmary, Glasgow, G31 2ER

Naveed Sattar

Pathological Biochemistry, Glasgow Royal Infirmary, Glasgow, G31 2ER

John Petrie

University Departments of Medicine, Glasgow Royal Infirmary, Glasgow, G31 2ER, jrp1s{at}clinmed.gla.ac.uk

Recent discoveries suggest that adipose tissue can synthesise and secrete mediators that contribute to the pathogenesis of type 2 diabetes mellitus and cardiovascular disease, leading to the concept of `adipose tissue as an endocrine organ'. These mediators include tumour necrosis factor-{alpha}, interleukin-6, adiponectin, resistin, plasminogen activator inhibitor type 1 and angiotensin II. They modify the activity of regulatory enzymes in adipocyte metabolism, alter the release of non-esterified fatty acids and affect glucose uptake. They may also have direct actions on the vascular endothelium. The diverse effects of these mediators support the notion that inflammation plays a role in metabolic and vascular disease, at least in part via adipocyte-derived cytokines.

Key Words: adipocytes • cytokines • insulin resistance • non-esterified fatty acids.

The British Journal of Diabetes & Vascular Disease, Vol. 1, No. 2, 110-114 (2001)
DOI: 10.1177/14746514010010020801
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?